Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia

M. Iino, K. Goto, W. Kakegawa, H. Okado, M. Sudo, S. Ishiuchi, A. Miwa, Y. Takayasu, I. Saito, K. Tsuzuki, S. Ozawa

研究成果: Article

301 引用 (Scopus)

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Glial cells express a variety of neurotransmitter receptors. Notably, Bergmann glial cells in the cerebellum have Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) assembled without the GluR2 subunit. To elucidate the role of these Ca2+-permeable AMPARs, we converted them into Ca2+-impermeable receptors by adenoviral-mediated delivery of the GluR2 gene. This conversion retracted the glial processes ensheathing synapses on Purkinje cell dendritic spines and retarded the removal of synaptically released glutamate. Furthermore, it caused multiple innervation of Purkinje cells by the climbing fibers. Thus, the glial Ca2+-permeable AMPARs are indispensable for proper structural and functional relations between Bergmann glia and glutamatergic synapses.

元の言語English
ページ(範囲)926-929
ページ数4
ジャーナルScience
292
発行部数5518
DOI
出版物ステータスPublished - 2001 5 4
外部発表Yes

ASJC Scopus subject areas

  • General

フィンガープリント Glia-synapse interaction through Ca<sup>2+</sup>-permeable AMPA receptors in Bergmann glia' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Iino, M., Goto, K., Kakegawa, W., Okado, H., Sudo, M., Ishiuchi, S., Miwa, A., Takayasu, Y., Saito, I., Tsuzuki, K., & Ozawa, S. (2001). Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia. Science, 292(5518), 926-929. https://doi.org/10.1126/science.1058827