Global gene expression analysis following spinal cord injury in non-human primates

Soraya Nishimura, Takashi Sasaki, Atsushi Shimizu, Kenji Yoshida, Hiroki Iwai, Ikuko Koya, Yoshiomi Kobayashi, Go Itakura, Shinsuke Shibata, Hayao Ebise, Keisuke Horiuchi, Jun Kudo, Yoshiaki Toyama, Aileen J. Anderson, Hideyuki Okano, Masaya Nakamura

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Spinal cord injury (SCI) is a devastating condition with no established treatment. To better understand the pathology and develop a treatment modality for SCI, an understanding of the physiological changes following SCI at the molecular level is essential. However, studies on SCI have primarily used rodent models, and few studies have examined SCI in non-human primates. In this study, we analyzed the temporal changes in gene expression patterns following SCI in common marmosets (Callithrix jacchus) using microarray analysis and mRNA deep sequencing. This analysis revealed that, although the sequence of events is comparable between primates and rodents, the inflammatory response following SCI is significantly prolonged and the onset of glial scar formation is temporally delayed in primates compared with rodents. These observations indicate that the optimal time window to treat SCI significantly differs among different species. This study provides the first extensive analysis of gene expression following SCI in non-human primates and will serve as a valuable resource in understanding the pathology of SCI.

本文言語English
ページ(範囲)171-179
ページ数9
ジャーナルExperimental Neurology
261
DOI
出版ステータスPublished - 2014 11月

ASJC Scopus subject areas

  • 神経学
  • 発達神経科学

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