Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response

Amane Konishi, Junpei Suzuki, Makoto Kuwahara, Akira Matsumoto, Shunsuke Nomura, Tomoyoshi Soga, Toshihiro Yorozuya, Masakatsu Yamashita

研究成果: Article査読

抄録

Glucocorticoids (GCs), immunosuppressive, and anti-inflammatory agents have various effects on T cells. However, the long-term influence of GCs on the T cell-mediated immune response remain to be elucidated. We demonstrated that the administration of GC during the TCR-mediated activation phase induced long-lasting suppression of glycolysis, even after the withdrawal of GC. The acquisition of the effector functions was inhibited, while the expression of PD-1 was increased in CD8 T cells activated in the presence of GC. Furthermore, adoptive transfer experiments revealed that GC-treated CD8 T cells reduced memory T cell formation and anti-tumor activity. These findings reveal that GCs have long-lasting influence on the T cell-mediated immune response via modulation of T cell metabolism.

本文言語English
ページ(範囲)34-40
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
588
DOI
出版ステータスPublished - 2022 1月 15

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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