Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells

Andrew Chojnacki, Takuya Shimazaki, Christopher Gregg, Gerry Weinmaster, Samuel Weiss

研究成果: Article

139 引用 (Scopus)

抄録

Glycoprotein130 (gp130) and Notch signaling are thought to participate in neural stem cell (NSC) self-renewal. We asked whether gp130 regulates Notch activity in forebrain epidermal growth factor (EGF)-responsive NSCs. Disruption of Notch1 using antisense or a γ-secretase inhibitor demonstrated a requirement for Notch1 in the maintenance and proliferation of NSCs. Ciliary neurotrophic factor (CNTF) activation of gp130 in NSCs rapidly increased Notch1 expression. NOTCH1 activation, indicated by tumor necrosis factor α-converting enzyme (TACE)- and presenilin-mediated processing, also increased. Infusion of EGF + CNTF into adult forebrain lateral ventricles increased periventricular NOTCH 1 compared with EGF alone. Neither Hes1 (hairy and enhancer of split) nor Hes5 appeared to mediate gp130-enhanced NOTCH1 signaling that regulates NSC maintenance. This is the first example of a link between gp130 signaling and NOTCH1 in regulating NSC self-renewal.

元の言語English
ページ(範囲)1730-1741
ページ数12
ジャーナルJournal of Neuroscience
23
発行部数5
出版物ステータスPublished - 2003 3 1

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Neural Stem Cells
Prosencephalon
Epidermal Growth Factor
Ciliary Neurotrophic Factor
Glycoproteins
Maintenance
Presenilins
Amyloid Precursor Protein Secretases
Lateral Ventricles
Tumor Necrosis Factor-alpha
Cell Self Renewal

ASJC Scopus subject areas

  • Neuroscience(all)

これを引用

Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells. / Chojnacki, Andrew; Shimazaki, Takuya; Gregg, Christopher; Weinmaster, Gerry; Weiss, Samuel.

:: Journal of Neuroscience, 巻 23, 番号 5, 01.03.2003, p. 1730-1741.

研究成果: Article

Chojnacki, Andrew ; Shimazaki, Takuya ; Gregg, Christopher ; Weinmaster, Gerry ; Weiss, Samuel. / Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells. :: Journal of Neuroscience. 2003 ; 巻 23, 番号 5. pp. 1730-1741.
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