Glycosyl 2-pyridinecarboxylate as an effective glycosyl donor: Glycosidation of mannose, 2-azidosugar, and 2-deoxysugar into disaccharides

Hironori Furukawa, Kazunori Koide, Ken Ichi Takao, Susumu Kobayashi

研究成果: Article

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Glycosylation reactions using a glycosyl 2-pyridinecarboxylate as a glycosyl donor were performed. Glycosyl 2-pyridinecarboxylate was designed based on a variation of the Remote Activation Concept and is activated through bidentate coordination to mild Lewis acids such as copper triflate and tin triflate. This method was effective for the glycosidation of not only glucose, but several other sugars such as the mannose-type, 2-azidosugar- type, and 2-deoxysugar-type. Various disaccharides were obtained in excellent yield by this reaction.

元の言語English
ページ(範囲)1244-1247
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
46
発行部数8
DOI
出版物ステータスPublished - 1998 1 1
外部発表Yes

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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