Grading criteria for disease severity by pemphigus disease area index

Tomoko Shimizu, Toru Takebayashi, Yuji Sato, Hironori Niizeki, Yumi Aoyama, Yasuo Kitajima, Keiji Iwatsuki, Takashi Hashimoto, Jun Yamagami, Victoria P. Werth, Masayuki Amagai, Akiko Tanikawa

研究成果: Article

16 引用 (Scopus)

抄録

Pemphigus is a group of autoimmune blistering diseases that affect the skin and mucous membranes. A reliable and accurate disease severity tool to assess pemphigus severity is crucial for managing pemphigus and for clinical trials. The purpose of this study was to compare the pemphigus disease area index activity score (PDAI), the Japanese pemphigus disease severity score (JPDSS) and the physician's subjective impression, and also to find appropriate severity grading cut-offs for the PDAI. We also evaluated the correlation between PDAI activity score and the JPDSS. Thirty-seven pemphigus patients and 110 assessments were analyzed in this study. The optimal points of pemphigus disease severity score in PDAI were: mild (0-8), moderate (9-24) and severe (≥25). In mild or moderate cases, the JPDSS was well correlated with the PDAI, but in severe cases the JPDSS reached a plateau at a PDAI score of approximately 30. The PDAI evaluates disease severity more accurately than the JPDSS, particularly in severe cases. The PDAI is not only a useful tool to measure the extent of cutaneous lesions, but also an excellent scoring system for evaluating pemphigus disease severity.

元の言語English
ページ(範囲)969-973
ページ数5
ジャーナルJournal of Dermatology
41
発行部数11
DOI
出版物ステータスPublished - 2014 11 1

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Pemphigus
Skin

ASJC Scopus subject areas

  • Dermatology

これを引用

Grading criteria for disease severity by pemphigus disease area index. / Shimizu, Tomoko; Takebayashi, Toru; Sato, Yuji; Niizeki, Hironori; Aoyama, Yumi; Kitajima, Yasuo; Iwatsuki, Keiji; Hashimoto, Takashi; Yamagami, Jun; Werth, Victoria P.; Amagai, Masayuki; Tanikawa, Akiko.

:: Journal of Dermatology, 巻 41, 番号 11, 01.11.2014, p. 969-973.

研究成果: Article

Shimizu, T, Takebayashi, T, Sato, Y, Niizeki, H, Aoyama, Y, Kitajima, Y, Iwatsuki, K, Hashimoto, T, Yamagami, J, Werth, VP, Amagai, M & Tanikawa, A 2014, 'Grading criteria for disease severity by pemphigus disease area index', Journal of Dermatology, 巻. 41, 番号 11, pp. 969-973. https://doi.org/10.1111/1346-8138.12649
Shimizu, Tomoko ; Takebayashi, Toru ; Sato, Yuji ; Niizeki, Hironori ; Aoyama, Yumi ; Kitajima, Yasuo ; Iwatsuki, Keiji ; Hashimoto, Takashi ; Yamagami, Jun ; Werth, Victoria P. ; Amagai, Masayuki ; Tanikawa, Akiko. / Grading criteria for disease severity by pemphigus disease area index. :: Journal of Dermatology. 2014 ; 巻 41, 番号 11. pp. 969-973.
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