Granuloma caused by subcutaneous injection of leuprorelin acetate product: Case report and histopathological findings

Takeshi Ouchi, Tetushi Koyama, Naho Miyata, Makoto Sugiura

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Leuprorelin acetate is a luteinizing hormone-releasing hormone (LH-RH) analog, which is used for chemical castration. Chemical castration treatment has an especially important role for prostate cancer. To ensure ongoing chemical castration, a novel sustained-action injection system using spherical microcapsules has been developed. We report a patient who had granuloma caused by administration of the 11.25 mg leuprorelin acetate product. Histological examination revealed many giant cells with vacuoles. On the basis of reported cases, these vacuoles are characteristic for the granuloma caused by leuprorelin acetate product. The vacuoles in the granuloma are the same size as the microcapsules, and their shape is almost spherical. We assume that the vacuoles in the granuloma are actually the microcapsules. We expect that there will be investigations regarding the procatarctic cause of granuloma formation.

本文言語English
ページ(範囲)719-721
ページ数3
ジャーナルJournal of Dermatology
33
10
DOI
出版ステータスPublished - 2006 10月 1
外部発表はい

ASJC Scopus subject areas

  • 皮膚病学

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