Graphical and analytic criteria for the existence of protein level oscillations in cyclic gene regulatory networks

Yutaka Hori, Tae Hyoung Kim, Shinji Hara

研究成果: Conference contribution

8 引用 (Scopus)

抜粋

This paper investigates the criteria for the existence of protein level oscillations in a class of gene regulatory networks, where a nonlinear differential equation model is considered to analyze its dynamical behavior. There are two steps to derive such criteria: We first employ a Poincaŕe-Bendixson type theorem to restrict the class of solution trajectories, and then carry out a local stability analysis of linearized systems with a generalized frequency variable. Then, our main results, graphical and its equivalent analytic criteria which are easily applicable for the networks consisting of arbitrary number of genes, are derived. Their distinctive features are also verified through numerical simulations.

元の言語English
ホスト出版物のタイトルProceedings of the 48th IEEE Conference on Decision and Control held jointly with 2009 28th Chinese Control Conference, CDC/CCC 2009
ページ3521-3526
ページ数6
DOI
出版物ステータスPublished - 2009 12 1
外部発表Yes
イベント48th IEEE Conference on Decision and Control held jointly with 2009 28th Chinese Control Conference, CDC/CCC 2009 - Shanghai, China
継続期間: 2009 12 152009 12 18

出版物シリーズ

名前Proceedings of the IEEE Conference on Decision and Control
ISSN(印刷物)0191-2216

Other

Other48th IEEE Conference on Decision and Control held jointly with 2009 28th Chinese Control Conference, CDC/CCC 2009
China
Shanghai
期間09/12/1509/12/18

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Modelling and Simulation
  • Control and Optimization

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  • これを引用

    Hori, Y., Kim, T. H., & Hara, S. (2009). Graphical and analytic criteria for the existence of protein level oscillations in cyclic gene regulatory networks. : Proceedings of the 48th IEEE Conference on Decision and Control held jointly with 2009 28th Chinese Control Conference, CDC/CCC 2009 (pp. 3521-3526). [5400718] (Proceedings of the IEEE Conference on Decision and Control). https://doi.org/10.1109/CDC.2009.5400718