Health-related QOL of elderly patients with pulmonary M. avium complex disease in a university hospital

T. Asakura, M. Ishii, K. Ishii, S. Suzuki, H. Namkoong, S. Okamori, H. Kamata, K. Yagi, Y. Funatsu, T. Betsuyaku, N. Hasegawa

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Background: Little is known about the clinical characteristics and health-related quality of life (HQOL) of elderly patients with pulmonary Mycobacterium avium complex (pMAC) disease. Objectives : To evaluate HQOL using the 36-Item Short-Form Health Survey and St George's Respiratory Questionnaire (SGRQ) and to investigate the predictors of HQOL changes among elderly patients with pMAC disease. Methods : This prospective cohort registry was conducted at Keio University Hospital, Tokyo, Japan, between May 2012 and July 2015 and included 84 patients with pMAC disease aged ≥75 years who had completed the HQOL questionnaire and 48 patients with pMAC disease who had been followed up and completed the HQOL questionnaire in cross-sectional and longitudinal analyses, respectively. Results : In cross-sectional analyses, elderly patients with pMAC disease had significantly lower rolephysical, general health, vitality, social functioning, role-emotional and role/social component scores than the general Japanese elderly population. Analysis of covariance revealed that patients with cavitary lesions had significantly worse physical functioning and SGRQ scores (P < 0.05). Longitudinal analysis showed that under-treatment, short duration of disease and positive sputum smear at baseline were predictors of worse HQOL at 12 months. Conclusions : Elderly patients with pMAC disease have reduced HQOL. Further large studies on HQOL are required to refine the use of this parameter in the treatment of these patients.

本文言語English
ページ(範囲)695-703
ページ数9
ジャーナルInternational Journal of Tuberculosis and Lung Disease
22
6
DOI
出版ステータスPublished - 2018 6 1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

フィンガープリント 「Health-related QOL of elderly patients with pulmonary M. avium complex disease in a university hospital」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル