Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum

Midori A. Arai, Ryuta Akamine, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

研究成果: Article査読

15 被引用数 (Scopus)

抄録

The inhibition of the hedgehog (Hh) signaling pathway has emerged as an attractive anti-cancer strategy. As part of our continuing search for natural inhibitors of the Hh/GLI1 signaling pathway, we isolated three alkaloids (1-3) from Crinum asiaticum. Compounds 1 and 3 showed potent Hh/GLI1-mediated transcriptional inhibitory activity and exhibited cytotoxicity against human pancreatic (PANC1) and prostate (DU145) cancer cells. Our data revealed that compounds 1 and 3 clearly inhibited the Hh signaling pathway by down-regulating the expression of GLI-related proteins (PTCH and BCL2) in DU145 cells.

本文言語English
ページ(範囲)538-542
ページ数5
ジャーナルJournal of Natural Medicines
69
4
DOI
出版ステータスPublished - 2015 10 11
外部発表はい

ASJC Scopus subject areas

  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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