Helper T cell diversity and plasticity

Shingo Nakayamada, Hayato Takahashi, Yuka Kanno, John J. O'Shea

研究成果: Review article査読

239 被引用数 (Scopus)

抄録

CD4 + helper T cells play crucial roles for host defense and immune-mediated disease by their ability to differentiate into specialized subsets. These subsets attain restricted patterns of cytokine secretion and specific expression of master transcription factors in response to microbial pathogens. Classically, the various helper CD4 + T cell subsets have been viewed as terminally differentiated lineages with limited flexibility. However, following the recognition of new subsets, there is increased recognition of plasticity. In this review, we highlight recent advances that pertain to this topic and the mechanisms that contribute to helper CD4 + T cell differentiation and plasticity.

本文言語English
ページ(範囲)297-302
ページ数6
ジャーナルCurrent Opinion in Immunology
24
3
DOI
出版ステータスPublished - 2012 6月
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

フィンガープリント

「Helper T cell diversity and plasticity」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル