Helper t cell plasticity: Impact of extrinsic and intrinsic signals on transcriptomes and epigenomes

Michael Bonelli, Han Yu Shih, Kiyoshi Hirahara, Kentner Singelton, Arian Laurence, Amanda Poholek, Tim Hand, Yohei Mikami, Golnaz Vahedi, Yuka Kanno, John J. O’Shea

研究成果: Article査読

36 被引用数 (Scopus)

抄録

CD4+ helper T cells are crucial for autoimmune and infectious diseases; however, the recognition of the many, diverse fates available continues unabated. Precisely what controls specification of helper T cells and preserves phenotypic commitment is currently intensively investigated. In this review, we will discuss the major factors that impact helper T cell fate choice, ranging from cytokines and the microbiome to metabolic control and epigenetic regulation. We will also discuss the technological advances along with the attendant challenges presented by “big data,” which allow the understanding of these processes on comprehensive scales.

本文言語English
ページ(範囲)279-326
ページ数48
ジャーナルCurrent topics in microbiology and immunology
381
DOI
出版ステータスPublished - 2015
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 微生物学
  • 免疫学
  • 微生物学(医療)

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