Hemangioendothelial sarcoma in brown adipose tissue of mouse induced by carcinogenic heterocyclic amine, Glu-P-1

M. Sakamoto, S. Takayama, Y. Hosoda

研究成果: Article査読

2 被引用数 (Scopus)

抄録

2-Amino-6-methyldipyrido[1,2-a:3',2'-d]limidazole, a potent bacterial mutagen from glutamic acid pyrolysate, when give to male CDF1 mice at a concentration of 0.05% in the diet induced blood vessel tumors characterized histopathologically. These hemangioendothelial sarcomas showed positive alkaline phosphatase activity histochemically and Weibel-Palade bodies ultrastructurally. Neoplasms were predilective for brown adipose tissue and foci of atypical cells, not peliosis-like lesions, appear to be an early stage in tumor development.

本文言語English
ページ(範囲)754-758
ページ数5
ジャーナルToxicologic Pathology
17
4 II
DOI
出版ステータスPublished - 1989
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 分子生物学
  • 毒物学
  • 細胞生物学

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