抜粋
2-Amino-6-methyldipyrido[1,2-a:3',2'-d]limidazole, a potent bacterial mutagen from glutamic acid pyrolysate, when give to male CDF1 mice at a concentration of 0.05% in the diet induced blood vessel tumors characterized histopathologically. These hemangioendothelial sarcomas showed positive alkaline phosphatase activity histochemically and Weibel-Palade bodies ultrastructurally. Neoplasms were predilective for brown adipose tissue and foci of atypical cells, not peliosis-like lesions, appear to be an early stage in tumor development.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 754-758 |
| ページ数 | 5 |
| ジャーナル | Toxicologic Pathology |
| 巻 | 17 |
| 発行部数 | 4 II |
| 出版物ステータス | Published - 1989 12 1 |
フィンガープリント
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Toxicology
- Cell Biology
これを引用
Sakamoto, M., Takayama, S., & Hosoda, Y. (1989). Hemangioendothelial sarcoma in brown adipose tissue of mouse induced by carcinogenic heterocyclic amine, Glu-P-1. Toxicologic Pathology, 17(4 II), 754-758.