TY - JOUR
T1 - Hemangioendothelial sarcoma in brown adipose tissue of mouse induced by carcinogenic heterocyclic amine, Glu-P-1
AU - Sakamoto, M.
AU - Takayama, S.
AU - Hosoda, Y.
PY - 1989
Y1 - 1989
N2 - 2-Amino-6-methyldipyrido[1,2-a:3',2'-d]limidazole, a potent bacterial mutagen from glutamic acid pyrolysate, when give to male CDF1 mice at a concentration of 0.05% in the diet induced blood vessel tumors characterized histopathologically. These hemangioendothelial sarcomas showed positive alkaline phosphatase activity histochemically and Weibel-Palade bodies ultrastructurally. Neoplasms were predilective for brown adipose tissue and foci of atypical cells, not peliosis-like lesions, appear to be an early stage in tumor development.
AB - 2-Amino-6-methyldipyrido[1,2-a:3',2'-d]limidazole, a potent bacterial mutagen from glutamic acid pyrolysate, when give to male CDF1 mice at a concentration of 0.05% in the diet induced blood vessel tumors characterized histopathologically. These hemangioendothelial sarcomas showed positive alkaline phosphatase activity histochemically and Weibel-Palade bodies ultrastructurally. Neoplasms were predilective for brown adipose tissue and foci of atypical cells, not peliosis-like lesions, appear to be an early stage in tumor development.
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U2 - 10.1177/0192623389017004203
DO - 10.1177/0192623389017004203
M3 - Article
C2 - 2626666
AN - SCOPUS:0024954935
VL - 17
SP - 754
EP - 758
JO - Toxicologic Pathology
JF - Toxicologic Pathology
SN - 0192-6233
IS - 4 II
ER -