Heparanase as a molecular target of cancer chemotherapy

Siro Simizu, Keisuke Ishida, Hiroyuki Osada

研究成果: Review article査読

67 被引用数 (Scopus)

抄録

Cancer cells require the ability to degrade the extracellular matrix (ECM) in order to turn into invasive and metastatic cancer cells. Many proteases and glycosidases are essential in the process of dissolving the components of the ECM. An endo-β-D-glucuronidase, heparanase, is capable of specifically degrading one of the ECM components, heparan sulfate, and this activity is associated with the metastatic potential of tumor cells. Since heparanase mRNA is overexpressed in many human tumors (e.g., hepatomas, head and neck tumors, and esophageal carcinomas), the mechanisms regulating the activity of heparanase should be clarified; considering the possible role of heparanase in cancer, the development of heparanase inhibitors would appear to be advantageous. This review will focus on recent findings that have contributed to the characterization of heparanase and to the elucidation of the transcriptional regulation of heparanase mRNA expression, as well as the development of heparanase inhibitors.

本文言語English
ページ(範囲)553-558
ページ数6
ジャーナルCancer science
95
7
DOI
出版ステータスPublished - 2004 7月 1
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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