Hepatic Tissue Oxygen Tension and Regional Hepatic Blood Volume in Alcoholic Fatty Liver

Takenobu Kamada, Nobuhiro Sato, Haruya Meren, Atsuo Inoue, Akinori Kasahara, Harumasa Yoshihara, Yutaka Sasaki, Norio Hayashi, Hideyuki Fusamoto, Hiroshi Abe, Yutaka Kishida, Toshikazu Takagi, Shinzou Kato, Hiromasa Ishii, Masaharu Tsuchiya

研究成果: Article

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In vivo hepatic tissue oxygen tension (hepatic tissue PO2) and regional hepatic blood volume were investigated by thin needle oxygen electrode and organ-reflectance spectrophotometry in chronically ethanol treated and pair-fed control rats. The hepatic tissue PO2 in chronically ethanol treated rats (7.1 ± 2.9 mmHg) was significantly lower than that in control rats (16.6 ± 8.8 mmHg). In chronically ethanol treated rats, the regional hepatic blood volume was signifcantly lower as compared with that in control rats. After acute oral ethanol administration (1 g/kg BW), the hepatic tissue PO2 in control rats increased about twofolds over basal level, while in chronically ethanol treated rats, the hepatic tissue PO2 decreased transiently, followed by a gradual increase. The increase of regional hepatic blood volume in chronically ethanol treated rats (4.9%) was lower than that in control rats (8.4%). It is concluded that in rats the liver was hypoxic even in the stage of fatty liver, probably due to the decreased hepatic blood supply.

元の言語English
ページ(範囲)1019-1023
ページ数5
ジャーナルNippon Shokakibyo Gakkai Zasshi
81
発行部数4
DOI
出版物ステータスPublished - 1984 1
外部発表Yes

ASJC Scopus subject areas

  • Gastroenterology

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    Kamada, T., Sato, N., Meren, H., Inoue, A., Kasahara, A., Yoshihara, H., Sasaki, Y., Hayashi, N., Fusamoto, H., Abe, H., Kishida, Y., Takagi, T., Kato, S., Ishii, H., & Tsuchiya, M. (1984). Hepatic Tissue Oxygen Tension and Regional Hepatic Blood Volume in Alcoholic Fatty Liver. Nippon Shokakibyo Gakkai Zasshi, 81(4), 1019-1023. https://doi.org/10.11405/nisshoshi1964.81.1019