Hepatic Tissue Oxygen Tension and Regional Hepatic Blood Volume in Alcoholic Fatty Liver

Takenobu Kamada, Nobuhiro Sato, Haruya Meren, Atsuo Inoue, Akinori Kasahara, Harumasa Yoshihara, Yutaka Sasaki, Norio Hayashi, Hideyuki Fusamoto, Hiroshi Abe, Yutaka Kishida, Toshikazu Takagi, Shinzo Kato, Hiromasa Ishii, Masaharu Tsuchiya

研究成果: Article

3 引用 (Scopus)

抄録

In vivo hepatic tissue oxygen tension (hepatic tissue PO2) and regional hepatic blood volume were investigated by thin needle oxygen electrode and organ-reflectance spectrophotometry in chronically ethanol treated and pair-fed control rats. The hepatic tissue PO2 in chronically ethanol treated rats (7.1 ± 2.9 mmHg) was significantly lower than that in control rats (16.6 ± 8.8 mmHg). In chronically ethanol treated rats, the regional hepatic blood volume was signifcantly lower as compared with that in control rats. After acute oral ethanol administration (1 g/kg BW), the hepatic tissue PO2 in control rats increased about twofolds over basal level, while in chronically ethanol treated rats, the hepatic tissue PO2 decreased transiently, followed by a gradual increase. The increase of regional hepatic blood volume in chronically ethanol treated rats (4.9%) was lower than that in control rats (8.4%). It is concluded that in rats the liver was hypoxic even in the stage of fatty liver, probably due to the decreased hepatic blood supply.

元の言語English
ページ(範囲)1019-1023
ページ数5
ジャーナルNippon Shokakibyo Gakkai Zasshi
81
発行部数4
DOI
出版物ステータスPublished - 1984
外部発表Yes

Fingerprint

Alcoholic Fatty Liver
Blood Volume
Oxygen
Liver
Ethanol
Spectrophotometry
Fatty Liver
Needles
Oral Administration
Electrodes

ASJC Scopus subject areas

  • Gastroenterology

これを引用

Kamada, T., Sato, N., Meren, H., Inoue, A., Kasahara, A., Yoshihara, H., ... Tsuchiya, M. (1984). Hepatic Tissue Oxygen Tension and Regional Hepatic Blood Volume in Alcoholic Fatty Liver. Nippon Shokakibyo Gakkai Zasshi, 81(4), 1019-1023. https://doi.org/10.11405/nisshoshi1964.81.1019

Hepatic Tissue Oxygen Tension and Regional Hepatic Blood Volume in Alcoholic Fatty Liver. / Kamada, Takenobu; Sato, Nobuhiro; Meren, Haruya; Inoue, Atsuo; Kasahara, Akinori; Yoshihara, Harumasa; Sasaki, Yutaka; Hayashi, Norio; Fusamoto, Hideyuki; Abe, Hiroshi; Kishida, Yutaka; Takagi, Toshikazu; Kato, Shinzo; Ishii, Hiromasa; Tsuchiya, Masaharu.

:: Nippon Shokakibyo Gakkai Zasshi, 巻 81, 番号 4, 1984, p. 1019-1023.

研究成果: Article

Kamada, T, Sato, N, Meren, H, Inoue, A, Kasahara, A, Yoshihara, H, Sasaki, Y, Hayashi, N, Fusamoto, H, Abe, H, Kishida, Y, Takagi, T, Kato, S, Ishii, H & Tsuchiya, M 1984, 'Hepatic Tissue Oxygen Tension and Regional Hepatic Blood Volume in Alcoholic Fatty Liver', Nippon Shokakibyo Gakkai Zasshi, 巻. 81, 番号 4, pp. 1019-1023. https://doi.org/10.11405/nisshoshi1964.81.1019
Kamada, Takenobu ; Sato, Nobuhiro ; Meren, Haruya ; Inoue, Atsuo ; Kasahara, Akinori ; Yoshihara, Harumasa ; Sasaki, Yutaka ; Hayashi, Norio ; Fusamoto, Hideyuki ; Abe, Hiroshi ; Kishida, Yutaka ; Takagi, Toshikazu ; Kato, Shinzo ; Ishii, Hiromasa ; Tsuchiya, Masaharu. / Hepatic Tissue Oxygen Tension and Regional Hepatic Blood Volume in Alcoholic Fatty Liver. :: Nippon Shokakibyo Gakkai Zasshi. 1984 ; 巻 81, 番号 4. pp. 1019-1023.
@article{6effdf9bde3943e3a4e2f8b46a356de8,
title = "Hepatic Tissue Oxygen Tension and Regional Hepatic Blood Volume in Alcoholic Fatty Liver",
abstract = "In vivo hepatic tissue oxygen tension (hepatic tissue PO2) and regional hepatic blood volume were investigated by thin needle oxygen electrode and organ-reflectance spectrophotometry in chronically ethanol treated and pair-fed control rats. The hepatic tissue PO2 in chronically ethanol treated rats (7.1 ± 2.9 mmHg) was significantly lower than that in control rats (16.6 ± 8.8 mmHg). In chronically ethanol treated rats, the regional hepatic blood volume was signifcantly lower as compared with that in control rats. After acute oral ethanol administration (1 g/kg BW), the hepatic tissue PO2 in control rats increased about twofolds over basal level, while in chronically ethanol treated rats, the hepatic tissue PO2 decreased transiently, followed by a gradual increase. The increase of regional hepatic blood volume in chronically ethanol treated rats (4.9{\%}) was lower than that in control rats (8.4{\%}). It is concluded that in rats the liver was hypoxic even in the stage of fatty liver, probably due to the decreased hepatic blood supply.",
author = "Takenobu Kamada and Nobuhiro Sato and Haruya Meren and Atsuo Inoue and Akinori Kasahara and Harumasa Yoshihara and Yutaka Sasaki and Norio Hayashi and Hideyuki Fusamoto and Hiroshi Abe and Yutaka Kishida and Toshikazu Takagi and Shinzo Kato and Hiromasa Ishii and Masaharu Tsuchiya",
year = "1984",
doi = "10.11405/nisshoshi1964.81.1019",
language = "English",
volume = "81",
pages = "1019--1023",
journal = "Journal of Japanese Society of Gastroenterology",
issn = "0446-6586",
publisher = "Japanese Society of Gastroenterology",
number = "4",

}

TY - JOUR

T1 - Hepatic Tissue Oxygen Tension and Regional Hepatic Blood Volume in Alcoholic Fatty Liver

AU - Kamada, Takenobu

AU - Sato, Nobuhiro

AU - Meren, Haruya

AU - Inoue, Atsuo

AU - Kasahara, Akinori

AU - Yoshihara, Harumasa

AU - Sasaki, Yutaka

AU - Hayashi, Norio

AU - Fusamoto, Hideyuki

AU - Abe, Hiroshi

AU - Kishida, Yutaka

AU - Takagi, Toshikazu

AU - Kato, Shinzo

AU - Ishii, Hiromasa

AU - Tsuchiya, Masaharu

PY - 1984

Y1 - 1984

N2 - In vivo hepatic tissue oxygen tension (hepatic tissue PO2) and regional hepatic blood volume were investigated by thin needle oxygen electrode and organ-reflectance spectrophotometry in chronically ethanol treated and pair-fed control rats. The hepatic tissue PO2 in chronically ethanol treated rats (7.1 ± 2.9 mmHg) was significantly lower than that in control rats (16.6 ± 8.8 mmHg). In chronically ethanol treated rats, the regional hepatic blood volume was signifcantly lower as compared with that in control rats. After acute oral ethanol administration (1 g/kg BW), the hepatic tissue PO2 in control rats increased about twofolds over basal level, while in chronically ethanol treated rats, the hepatic tissue PO2 decreased transiently, followed by a gradual increase. The increase of regional hepatic blood volume in chronically ethanol treated rats (4.9%) was lower than that in control rats (8.4%). It is concluded that in rats the liver was hypoxic even in the stage of fatty liver, probably due to the decreased hepatic blood supply.

AB - In vivo hepatic tissue oxygen tension (hepatic tissue PO2) and regional hepatic blood volume were investigated by thin needle oxygen electrode and organ-reflectance spectrophotometry in chronically ethanol treated and pair-fed control rats. The hepatic tissue PO2 in chronically ethanol treated rats (7.1 ± 2.9 mmHg) was significantly lower than that in control rats (16.6 ± 8.8 mmHg). In chronically ethanol treated rats, the regional hepatic blood volume was signifcantly lower as compared with that in control rats. After acute oral ethanol administration (1 g/kg BW), the hepatic tissue PO2 in control rats increased about twofolds over basal level, while in chronically ethanol treated rats, the hepatic tissue PO2 decreased transiently, followed by a gradual increase. The increase of regional hepatic blood volume in chronically ethanol treated rats (4.9%) was lower than that in control rats (8.4%). It is concluded that in rats the liver was hypoxic even in the stage of fatty liver, probably due to the decreased hepatic blood supply.

UR - http://www.scopus.com/inward/record.url?scp=0021274852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021274852&partnerID=8YFLogxK

U2 - 10.11405/nisshoshi1964.81.1019

DO - 10.11405/nisshoshi1964.81.1019

M3 - Article

C2 - 6748312

AN - SCOPUS:0021274852

VL - 81

SP - 1019

EP - 1023

JO - Journal of Japanese Society of Gastroenterology

JF - Journal of Japanese Society of Gastroenterology

SN - 0446-6586

IS - 4

ER -