Hepatocyte-derived snail1 propagates liver fibrosis progression

R. Grant Rowe, Yongshun Lin, Ryoko Shimizu-Hirota, Shinichiro Hanada, Eric G. Neilson, Joel K. Greenson, Stephen J. Weiss

研究成果: Article査読

94 被引用数 (Scopus)

抄録

Chronic exposure of the liver to hepatotoxic agents initiates an aberrant wound healing response marked by proinflammatory, as well as fibrotic, changes, leading to compromised organ structure and function. In a variety of pathological states, correlative links have been established between tissue fibrosis and the expression of transcription factors associated with the induction of epithelial-mesenchymal cell transition (EMT) programs similar to those engaged during development. However, the role played by endogenously derived, EMT-associated transcription factors in fibrotic states in vivo remains undefined. Using a mouse model of acute liver fibrosis, we demonstrate that hepatocytes upregulate the expression of the zinc finger transcriptional repressor, Snail1, during tissue remodeling. Hepatocyte-specific ablation of Snail1 demonstrates that this transcription factor plays a key role in liver fibrosis progression in vivo by triggering the proximal genetic programs that control multiple aspects of fibrogenesis, ranging from growth factor expression and extracellular matrix biosynthesis to the ensuing chronic inflammatory responses that characterize this class of pathological disorders.

本文言語English
ページ(範囲)2392-2403
ページ数12
ジャーナルMolecular and cellular biology
31
12
DOI
出版ステータスPublished - 2011 6
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学

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