Hepatoprotective effect of Hovenia dulcis Thunb. on experimental liver injuries induced by carbon tetrachloride or D- galactosamine/lipopolysaccharide

Koji Hase, Mizue Ohsugi, Quanbo Xiong, Purusotam Basnet, Shigetoshi Kadota, Tsuneo Namba

研究成果: Article査読

61 被引用数 (Scopus)

抄録

The hepatoprotective effects of the fruits of Hovenia dulcis Thunb. on chemically or immunologically induced experimental liver injury models were examined. The methanol extract showed significant hepatoprotective activity against CCl4-toxicity in rats and D-galactosamine (D- GalN)/lipopolysaccharide-induced liver injury in mice. The methanol extract also significantly protected against CCl4-toxicity in primary cultured rat hepatocytes. Hepatoprotective activity-guided fractionation and chemical analysis led to the isolation of an active constituent. (+)-ampelopsin (1) from the methanol extract.

本文言語English
ページ(範囲)381-385
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
20
4
DOI
出版ステータスPublished - 1997 4月
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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