Hepatoprotective effects of traditional medicines. isolation of the active constituent from seeds of celosia argentea

Koji Hase, Shigetoshi Kadota, Purusotam Basnet, Tsuneo Namba, Tooru Takahashi

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The hepatoprotective effects of water extracts from twelve crude drugs were investigated. Among them, the water extracts of Cassia obtusifolia, Celosia argentea, Cucurbita moschata and Curcuma aeruginosa showed a significant protective effect on carbon tetrachloride induced liver injury in rats and D-galactosamine (D-GalN)/lipopolysaccharide (LPS) induced liver injury in mice. The water extract of C. argentea was found to be the most effective. The hepatoprotective activity guided fractionation of this extract led to the isolation of an active constituent. This component was named as celosian, and was found to be an acidic heteroglycan (molecular weight: 1.9 × 105) containing 4% of proteins.

本文言語English
ページ(範囲)387-392
ページ数6
ジャーナルPhytotherapy Research
11
8
出版ステータスPublished - 1997 12 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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