Hereditary cataract of the Nakano mouse

Makoto Takehana

研究成果: Article査読

29 被引用数 (Scopus)

抄録

The Nakano mouse is a hereditary cataract model whose most characteristic change is a deficiency in lens Na+,K+-ATPase. Consequently, there is a change in lenticular sodium and potassium ion levels just before cataract formation. The amounts of calcium ion also change suddenly in the lens, with accumulated levels higher than any other type of cataract. Other biochemical changes coincide with the development of lens opacity, including decreases in the levels of reduced glutathione, ATP, biosynthetic activity of proteoglycans in epithelial cells, and the permeability of gap junction channels in fiber cells. The decrease in the activity of Na+,K+-ATPase results in changes in a number of key metabolic parameters, resulting in the eventual opacification of the Nakano mouse lens at approximately 30 days of age.

本文言語English
ページ(範囲)671-676
ページ数6
ジャーナルExperimental Eye Research
50
6
DOI
出版ステータスPublished - 1990 6月

ASJC Scopus subject areas

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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