Heterogeneity of Proliferative Activity in Nodule‐in‐Nodule Lesions of Small Hepatocellular Carcinoma

Yoshihiro Matsuno, Setsuo Hirohashi, Shuichiroh Furuya, Michiie Sakamoto, Kiyoshi Mukai, Yukio Shimosato

研究成果: Article査読

53 被引用数 (Scopus)


Surgically resected small hepatocellular carcinomas showing “nodule‐in‐nodule’formation were analyzed in terms of cell proliferative activity. The analysis was achieved by successful immunohistochemical demonstration of proliferating cell nuclear antigen in formalin‐fixed paraffin‐embedded tissue sections. Eight nodules (up to 3 cm in diameter) examined were either atypical adenomatous hyperplasia or hepatocellular carcinoma of low histologic grade, containing a discrete inner nodular area composed of obvious hepatocellular carcinoma of higher histologic grade. In all cases, the proliferating cell nuclear antigen labeling index of the latter area was much higher than that of the former, which in turn was slightly higher than that of the non‐cancerous liver of the patient in 6 cases. The data presented here provide supporting evidence that the successive emergence and expansion of a more rapidly proliferating subclone within a nodule result in the stepwise progression of malignancy of human hepatocellular carcinoma.

ジャーナルJapanese Journal of Cancer Research
出版ステータスPublished - 1990 11月

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究


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