High complete response rate after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning regimens in advanced malignant lymphoma

T. E. Tanimoto, E. Kusumi, T. Hamaki, K. Yuji, J. Ueyama, S. Miyakoshi, S. Morinaga, M. Kami, Y. Kanda, T. Ando, S. Yoshihara, S. Masuo, S. W. Kim, K. Nakai, K. Tobinai, R. Tanosaki, S. Mineishi, Y. Takaue, Y. Muto

研究成果: Article査読

20 被引用数 (Scopus)

抄録

The possible advantage of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a graft-versus-lymphoma effect. We explored the feasibility and efficacy of allo-HSCT with reduced-intensity (RI) regimens in advanced malignant lymphoma (ML). A total of 20 patients with indolent (n = 9) or aggressive lymphoma (n = 11) received allo-HSCT with an RI regimen (RIST). The preparative regimen consisted of a combination of purine analog and alkylating agent with or without antithymocyte globulin. A total of 11 patients had chemorefractory disease, seven had chemosensitive relapsed disease and two had residual disease. All of the patients received G-CSF-mobilized blood stem cells from HLA-matched siblings. Of the 20 patients, 19 achieved engraftment with acceptable regimen-related toxicities. Seven patients developed grade II-IV acute GVHD and 15 developed chronic GVHD. Of the 15 patients with evaluable disease, 12 achieved a complete response. One died of invasive fusariosis, four subsequently died of GVHD complicated with fungal infection and one died of progressive disease. With a median follow-up of 358 days, the Kaplan-Meier estimates for 1-year overall and progression-free survival were both 70%. The high response rate with low relapse observed in this study suggests that RIST may be an effective alternative curative treatment for patients with advanced ML.

本文言語English
ページ(範囲)131-137
ページ数7
ジャーナルBone Marrow Transplantation
32
2
DOI
出版ステータスPublished - 2003 7
外部発表はい

ASJC Scopus subject areas

  • 血液学
  • 移植

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