High frequency of inactivation of the imprinted H19 gene in 'sporadic' hepatoblastoma

Ryuji Fukuzawa, Akihiro Umezawa, Kensuke Ochi, Fumihiko Urano, Hitoshi Ikeda, Jun Ichi Hata

研究成果: Article査読

37 被引用数 (Scopus)

抄録

Embryonal tumors such as Wilms' tumor (WT), embryonal rhabdomyosarcoma (eRMS) and hepatoblastoma have been thought to have a common pathogenetic mechanism. H19 was found to be inactivated in WT and eRMS either by loss of heterozygosity or by hypermethylation of the maternal allele. We show here that the expression of the H19 gene is inactivated by maternal allelic loss or hypermethylation in 7 out of 8 'sporadic' hepatoblastomas. Furthermore, we analyzed expression of the IGF2 gene. Loss of imprinting of the IGF2 gene was detected and linked to inactivation of the H19 gene in 2 hepatoblastomas. However, 2 sporadic cases demonstrated monoallelic expression of the IGF2 gene with inactivation of the H19 gene. Our results suggest that H19 may play a role as a common imprinted tumor suppressor gene in 'sporadic' hepatoblastomas but may at times work independently of IGF2 expression.

本文言語English
ページ(範囲)490-497
ページ数8
ジャーナルInternational Journal of Cancer
82
4
DOI
出版ステータスPublished - 1999

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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