High frequency of Vα24+ Vβ11+ T-cells observed in type 1 diabetes

Yoichi Oikawa, Akira Shimada, Satoru Yamada, Yoshiko Motohashi, Yoshinori Nakagawa, Jun Ichiro Irie, Taro Maruyama, Takao Saruta

研究成果: Article

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OBJECTIVE - Natural killer T-cells (NKT cells) are believed to play an important role in the regulation of immune response, and a numerical and functional deficit of NKT cells has been reported to be associated with the pathogenesis of autoimmune diseases. Thus far, it has been shown that subjects with type 1 diabetes have a lower frequency of NKT cells than nondiabetic subjects. In this study, we measured the frequency of peripheral Vα24 + Vβ11+ T-cells, which include human NKT cells, in Japanese diabetic patients. RESEARCH DESIGN AND METHODS - Peripheral blood samples were obtained from 164 Japanese diabetic patients and 67 healthy subjects. The diabetic patients were classified into four categories as follows: islet-associated autoantibody-positive (Ab+) and -negative (Ab -) classic type 1 diabetes, latent autoimmune diabetes in adults (LADA), and type 2 diabetes. We measured the frequency of peripheral Vα24+ Vβ11+ CD3+ triple-positive cells. RESULTS - Unexpectedly, a higher frequency of Vα24+ Vβ11+ T-cells was observed in Ab+ and Ab- patients compared with LADA patients (P = 0.0294 and P = 0.0021), type 2 diabetic patients (P < 0.0001 and P < 0.0001), and healthy subjects (P = 0.0046 and P = 0.0001). Moreover, an inverse correlation between Vα24 + Vβ11+ T-cell frequency and disease duration was observed in Ab+ (p = -0.455; P = 0.0023) and Ab- (p = -0.432; P = 0.0162) patients. CONCLUSIONS - Our findings indicate that a high frequency of Vα24+ Vβ11+ T-cells is a unique finding in recent-onset classic type 1 diabetes, and measurement of Vα24+ Vβ11+ T-cell frequency may be useful to assess the disease activity of classic type 1 diabetes.

元の言語English
ページ(範囲)1818-1823
ページ数6
ジャーナルDiabetes care
25
発行部数10
DOI
出版物ステータスPublished - 2002 10 1

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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    Oikawa, Y., Shimada, A., Yamada, S., Motohashi, Y., Nakagawa, Y., Irie, J. I., Maruyama, T., & Saruta, T. (2002). High frequency of Vα24+ Vβ11+ T-cells observed in type 1 diabetes. Diabetes care, 25(10), 1818-1823. https://doi.org/10.2337/diacare.25.10.1818