High oxygen breathing improves inhomogeneities of ventilation-perfusion distributions in acutely injured lungs

K. Yamaguchi, M. Mori, T. Takashugi, Y. Oyamada, A. Kawai, K. Asano, T. Aoki, H. Fujita, Y. Suzuki

研究成果: Article査読

抄録

Using twenty-five mongrel dogs either with or without alveolar flooding induced by oleic acid administration, the effects of high oxygen breathing (60% O2) on ventilation-perfusion (V̇(A)/Q̇) distributions in the lungs were systematically investigated. V̇(A)/Q̇ distributions were examined by multiple inert gas elimination technique, from which the V̇(A)/Q̇ values describing mean positions of perfusion (Q̇) and ventilation (V̇(A)) distributions against the V̇(A)/Q̇ axis were calculated (mean Q̇ and mean V̇(A)). As the first measure of dispersion for V̇(A)/Q̇ distribution, the log standard deviation was estimated (log SD (Q̇) and log SD (V̇(A))). As the second measure of dispersion, the area under the curve, constructed by plotting inert gas arterial-to-alveolar partial pressure differences as a function of blood-gas partition coefficient, was calculated (aAD area). High oxygen breathing slightly enhanced the dispersion of V̇(A)/Q̇ distributions in the normal dogs but decreased that in the dogs injured with oleic acid. Therefore, we concluded that high oxygen breathing worsened the inhomogeneities of V̇(A)/Q̇ distributions in normal lungs but did improve those in acutely injured lungs.

本文言語English
ページ(範囲)739-746
ページ数8
ジャーナルJapanese Journal of Thoracic Diseases
32
8
出版ステータスPublished - 1994 1 1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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