High sulfotransferase activity for phenolic aromatic odorants present in the mouse olfactory organ

Hiro Omi Tamura, Atsushi Miyawaki, Naoko Inoh, Yuki Harada, Katsuhiko Mikoshiba, Michio Matsui

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Mouse nasal cytosols show high sulfotransferase (ST) activities toward phenolic aromatic odorants, but have little activities for most alcoholic aromatic odorants. Most ST activities toward the phenolic odorants preferred slightly acidic pH (6.4) and were sensitive to 2,6-dichloro-4-nitrophenol, a specific inhibitor for phenol ST (P-ST) but were not inhibited by triethylamine and tetra-n-butylammonium chloride, which are specific inhibitors for hydroxysteroid ST (HS-ST). These results suggested that P-ST activities are responsible for sulfation of the phenolic odorants. The spectra of the ST activities for these odorants were similar in mouse nasal and liver cytosols, however, nasal cytosols showed much higher ST activity toward cinnamyl alcohol than liver cytosols. This activity preferred higher pH (7.4) compared to the phenolic odorant-ST activities and was inhibited by both types of inhibitors, specific for P-ST and HS-ST. These results appear to indicate the participation of multiple ST isoforms for the sulfation of odorants in mouse nasal cytosols. The existence of P-ST(s) active for the phenolic odorants in olfactory cytosols suggests a role in odorant perception, in particular, in the signal termination process.

本文言語English
ページ(範囲)1-9
ページ数9
ジャーナルChemico-Biological Interactions
104
1
DOI
出版ステータスPublished - 1997 4 18

ASJC Scopus subject areas

  • 毒物学

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