Highly selective hydroxylation of benzene to phenol by wild-type cytochrome P450BM3 assisted by decoy molecules

Osami Shoji, Tatsuya Kunimatsu, Norifumi Kawakami, Yoshihito Watanabe

研究成果: Article査読

91 被引用数 (Scopus)

抄録

Playing tricks on enzymes: Direct hydroxylation of benzene to phenol was catalyzed by wild-type P450BM3 in the presence of perfluorinated carboxylic acids as decoy molecules. The catalytic turnover rate reached 120 min -1 per P450. The selectivity towards phenol production was very high and no overoxidation products were detected.

本文言語English
ページ(範囲)6606-6610
ページ数5
ジャーナルAngewandte Chemie - International Edition
52
26
DOI
出版ステータスPublished - 2013 6 24
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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