Hippocampal activity during serotonergic neuronal activity manipulation using optogenetics

D. Kondo, Y. Mitsukura, K. Yoshida, I. Tsutsui-Kimura, N. Takata, K. F. Tanaka

研究成果: Conference contribution

抄録

In order to improve brain dysfunction such as mental disease, it is necessary to clarify the mechanism of activity in the brain. To clarify the relationship between the brain region and the neurotransmitter is important for elucidating the brain. Especially investigating the relationship between serotonin and hippocampus leads to elucidate of the mechanism of depression and sleep. The technique called optogenetics enabled only specific cells to be manipulated by light stimulation in recent years. This technique is a useful technique for clarifying the function of the brain. Because instead of stimulating multiple cells such as electrical stimulation, optogenetics can stimulate only specific cells, so that its function can be clarified. This study focused on neurotransmitter serotonin and the brain region called the hippocampus. For these purpose we can clarify the relationship between serotonin and hippocampus by manipulating serotonin neural activity using optogenetics while invasively measuring the ventral hippocampus of the mouse. In addition, identification of pyramidal cell layer is necessary to clarify hippocampal activity. Currently, visual estimation is performed based on the histology that dissected the brain, it still has a problem. Now this technique can't estimate ambiguous of the brain part and measure in an online manner. For this problem, we focus on the clarity of the brain part estimation when we used optogenetics. Therefore, we could estimate the pyramidal cell layer of the hippocampus by analyzing nerve activity and thought that the effect of serotonin activation or suppression on the hippocampus could be clarified. As a result, we showed that pyramidal cell layer can be identified by using principal component analysis, and could clarify the variation of nerve activity in the pyramidal cell layer of hippocampus during serotonin operation.

本文言語English
ホスト出版物のタイトル2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings
出版社Institute of Electrical and Electronics Engineers Inc.
ページ1-6
ページ数6
ISBN(電子版)9781538648735
DOI
出版ステータスPublished - 2017 7 1
イベント2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Philadelphia, United States
継続期間: 2017 12 2 → …

出版物シリーズ

名前2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings
2018-January

Other

Other2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017
CountryUnited States
CityPhiladelphia
Period17/12/2 → …

ASJC Scopus subject areas

  • Signal Processing
  • Cardiology and Cardiovascular Medicine
  • Health Informatics
  • Clinical Neurology

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