Hippocampal ripples down-regulate synapses

Hiroaki Norimoto, Kenichi Makino, Mengxuan Gao, Yu Shikano, Kazuki Okamoto, Tomoe Ishikawa, Takuya Sasaki, Hiroyuki Hioki, Shigeyoshi Fujisawa, Yuji Ikegaya

研究成果: Article査読

116 被引用数 (Scopus)

抄録

The specific effects of sleep on synaptic plasticity remain unclear.We report that mouse hippocampal sharp-wave ripple oscillations serve as intrinsic events that trigger long-lasting synaptic depression. Silencing of sharp-wave ripples during slow-wave states prevented the spontaneous down-regulation of net synaptic weights and impaired the learning of new memories.The synaptic down-regulation was dependent on the N-methyl-D-aspartate receptor and selective for a specific input pathway.Thus, our findings are consistent with the role of slow-wave states in refining memory engrams by reducing recent memory-irrelevant neuronal activity and suggest a previously unrecognized function for sharp-wave ripples.

本文言語English
ページ(範囲)1524-1527
ページ数4
ジャーナルScience
359
6383
DOI
出版ステータスPublished - 2018 3月 30
外部発表はい

ASJC Scopus subject areas

  • 一般

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