Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: Synaptocrinology

H. Mukai, N. Takata, H. T. Ishii, N. Tanabe, Y. Hojo, A. Furukawa, T. Kimoto, S. Kawato

研究成果: Article査読

100 被引用数 (Scopus)

抄録

Hippocampal pyramidal neurons and granule neurons of adult male rats are equipped with a complete machinery for the synthesis of pregnenolone, dehydroepiandrosterone, testosterone, dihydrotestosterone and 17β-estradiol. Both estrogens and androgens are synthesized in male hippocampus. These brain steroids are synthesized by cytochrome P450s (P450scc, P45017α and P450arom), hydroxysteroid dehydrogenases and reductases from endogenous cholesterol. The expression levels of enzymes are as low as 1/300-1/1000 of those in endocrine organs. Synthesis is dependent on the acute Ca2+ influx upon neuron-neuron communication via NMDA receptors. Estradiol is particularly important because estradiol rapidly modulates neuronal synaptic transmission such as long-term potentiation via synaptic estrogen receptors. Xenoestrogens may also act via estrogen-driven signaling pathways.

本文言語English
ページ(範囲)757-764
ページ数8
ジャーナルNeuroscience
138
3
DOI
出版ステータスPublished - 2006
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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