Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia - reperfusion

Toshifumi Yoshida, Ryuichi Iwakiri, Takahiro Noda, Kazuyo Okamoto, Masataka Kojima, Koji Fukuyama, Kazuma Fujimoto

研究成果: Article査読

18 被引用数 (Scopus)


This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia - reperfusion in the rat intestine. The superior mesenteric artery was occluded for 60 min followed by reperfusion for 60 min. Rats were infused with H1-receptor antagonist (chlorpheniramine maleate) or H2-receptor antagonist (cimetidine). Additional rats were pretreated with aminoguanidine (100 mg/kg). Percent apoptosis in the intestinal mucosa increased after reperfusion, but neither H1 nor H2 antagonists had any effect on apoptosis. Aminoguanidine pretreatment inhibited activity of diamine oxidase and increased the plasma histamine concentration. Aminoguanidine attenuated the increase in mucosal apoptosis following reperfusion. Apoptosis induced by an ischemic insult to the intestinal mucosa was not related to an undesirable effect of histamine. Attenuation of increased intestinal apoptosis might be due to increased plasma histamine level and/or other pharmacological action of amioguanidine, including inhibition of inducible nitric oxide synthase.

ジャーナルDigestive Diseases and Sciences
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • 生理学
  • 消化器病学


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