Histone acetylation in reproductive organs: Significance of histone deacetylase inhibitors in gene transcription

Hiroshi Uchida, Tetsuo Maruyama, Toru Arase, Masanori Ono, Takashi Nagashima, Hirotaka Masuda, Hironori Asada, Yasunori Yoshimura

研究成果: Review article査読

9 被引用数 (Scopus)

抄録

Acetylation of histones is cooperatively regulated by two groups of enzymes, histone acetyltransferases and histone deacetylases. Histone acetylation status plays a fundamental role in the level of gene transcription; numerous studies have demonstrated that histone deacetylase inhibitors cause cell growth arrest, apoptosis, and differentiation in various cells including human mammary gland and endometrial cells by altering transcription of a small number of genes. A recent study has also shown that a highly acetylated histone status alters cell motility. After the present review of the published reports on the mechanisms underlying histone acetylation and in vitro effects of histone deacetylase inhibitors, we conclude that this class of agents may have potential not only as anticancer drugs, but also as inducers of differentiation and/or motility for benign gynecologic conditions such as endometriosis and disorders of endometrial differentiation and dysfunction.

本文言語English
ページ(範囲)115-122
ページ数8
ジャーナルReproductive Medicine and Biology
4
2
DOI
出版ステータスPublished - 2005 6

ASJC Scopus subject areas

  • 生殖医学
  • 細胞生物学

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