Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan

Kouji Harada, Akio Koizumi, Norimitsu Saito, Kayoko Inoue, Takeo Yoshinaga, Chigusa Date, Shigeo Fujii, Noriyuki Hachiya, Iwao Hirosawa, Shigeki Koda, Yukinori Kusaka, Katsuyuki Murata, Kazuyuki Omae, Shinichiro Shimbo, Katsunobu Takenaka, Tatsuya Takeshita, Hidemi Todoriki, Yasuhiko Wada, Takao Watanabe, Masayuki Ikeda

研究成果: Article

120 引用 (Scopus)

抜粋

Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) have recently received attention due to their widespread contamination in the environment, as well as in wildlife and humans. We measured the PFOS and PFOA concentrations in historically recorded human serum samples at an age range between 20 and 59 years collected in Kyoto, 20 persons per each time point (n = 100), and also the PFOS and PFOA concentrations in human serum samples at an age range between 20 and 59 years from 10 locations throughout Japan (n = 200). The historical samples collected from 1983 to 1999 demonstrated that the PFOA concentrations in males and females from Kyoto have increased 4.4-fold and 4.3-fold at a rate of increase of 0.49 ng/ml/year and 0.42 ng/ml/year, respectively. In contrast, serum concentrations of PFOS reached a plateau in the late 1980s. There are also regional differences in both the PFOS and PFOA serum concentrations. The concentrations in serum [geometric mean (geometric standard deviation)] (ng/ml) in 2003-2004 ranged from 7.6(1.6) in the town of Matsuoka in Fukui prefecture to 27.8(1.6) in Kyoto city, and ranged from 2.3(1.5) in Matsuoka to 14.5(1.3) in Osaka city for PFOS and PFOA, respectively.

元の言語English
ページ(範囲)293-301
ページ数9
ジャーナルChemosphere
66
発行部数2
DOI
出版物ステータスPublished - 2007 1

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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    Harada, K., Koizumi, A., Saito, N., Inoue, K., Yoshinaga, T., Date, C., Fujii, S., Hachiya, N., Hirosawa, I., Koda, S., Kusaka, Y., Murata, K., Omae, K., Shimbo, S., Takenaka, K., Takeshita, T., Todoriki, H., Wada, Y., Watanabe, T., & Ikeda, M. (2007). Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan. Chemosphere, 66(2), 293-301. https://doi.org/10.1016/j.chemosphere.2006.05.010