Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis

Reina Ariki, Satoru Morikawa, Yo Mabuchi, Sadafumi Suzuki, Mayuka Nakatake, Kentaro Yoshioka, Shinya Hidano, Hiromitsu Nakauchi, Yumi Matsuzaki, Takuro Nakamura, Ryo Goitsuka

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Hematopoietic stem cells in the bone marrow have the capacity to both self-renew and to generate all cells of the hematopoietic system. The balance of these two activities is controlled by hematopoietic stem cell-intrinsic regulatory mechanisms as well as extrinsic signals from the microenvironment. Here we demonstrate that Meis1, a TALE family homeodomain transcription factor involved in numerous embryonic developmental processes, is selectively expressed in hematopoietic stem/progenitor cells. Conditional Meis1 knockout in adult hematopoietic cells resulted in a significant reduction in the hematopoietic stem/progenitor cells. Suppression of hematopoiesis by Meis1 deletion appears to be caused by impaired self-renewal activity and reduced cellular quiescence of hematopoietic stem/progenitor cells in a cell autonomous manner, resulting in stem cell exhaustion and defective long-term hematopoiesis. Meis1 deficiency down-regulated a subset of Pbx1-dependent hematopoietic stem cell signature genes, suggesting a functional link between them in the maintenance of hematopoietic stem/progenitor cells. These results show the importance of Meis1 in adult hematopoiesis.

本文言語English
論文番号e87646
ジャーナルPloS one
9
2
DOI
出版ステータスPublished - 2014 2 3

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)
  • 農業および生物科学(全般)
  • 一般

フィンガープリント

「Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル