Homogeneous enantioselective catalysis in a continuous-flow microreactor: Highly enantioselective borohydride reduction of Ketones catalyzed by optically active cobalt complexes

Takuo Hayashi, Satoshi Kikuchi, Yukako Asano, Yoshishige Endo, Tohru Yamada

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Highly enantioselective homogeneous catalysis under continuous-flow conditions was established for the cobalt-catalyzed borohydride reduction of tetralone derivatives. A microreactor allowed higher reaction temperature with the residence time of 12 min than the corresponding batch system to maintain enantioselectivity as well as reactivity. The present system was directly applied to gram-scale synthesis to afford the reduced product with 92% ee.

本文言語English
ページ(範囲)1235-1240
ページ数6
ジャーナルOrganic Process Research and Development
16
6
DOI
出版ステータスPublished - 2012 6 15

ASJC Scopus subject areas

  • 物理化学および理論化学
  • 有機化学

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