TY - JOUR
T1 - Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata
AU - Iwasaki, Arihiro
AU - Tadenuma, Takato
AU - Sumimoto, Shimpe
AU - Shiota, Ikuma
AU - Matsubara, Teruhiko
AU - Saito-Nakano, Yumiko
AU - Nozaki, Tomoyoshi
AU - Sato, Toshinori
AU - Suenaga, Kiyotake
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Number 18K14346 and 16H03285. We thank Y. Umeki for technical assistance and the Japanese Red Cross Society for providing human RBCs and plasma.
PY - 2018/11/26
Y1 - 2018/11/26
N2 - Hoshinoamides A (1) and B (2), new acyclic lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata. Their structures were elucidated by spectroscopic analyses and degradation reactions. Hoshinoamides A (1) and B (2) did not exhibit any cytotoxicity against HeLa cells at 10 μM, but inhibited the in vitro growth of the malarial parasite Plasmodium falciparum (IC50 = 0.52 and 1.0 μM, respectively).
AB - Hoshinoamides A (1) and B (2), new acyclic lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata. Their structures were elucidated by spectroscopic analyses and degradation reactions. Hoshinoamides A (1) and B (2) did not exhibit any cytotoxicity against HeLa cells at 10 μM, but inhibited the in vitro growth of the malarial parasite Plasmodium falciparum (IC50 = 0.52 and 1.0 μM, respectively).
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U2 - 10.1021/acs.jnatprod.8b00643
DO - 10.1021/acs.jnatprod.8b00643
M3 - Article
C2 - 30387355
AN - SCOPUS:85056429291
SN - 0163-3864
VL - 81
SP - 2545
EP - 2552
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 11
ER -
