How selfish retrotransposons are silenced in Drosophila germline and somatic cells

Mikiko C. Siomi, Kuniaki Saito, Haruhiko Siomi

研究成果: Short survey査読

41 被引用数 (Scopus)

抄録

Transposable elements (TEs) are DNA elements found in the genomes of various organisms. TEs have been highly conserved during evolution, suggesting that they confer advantageous effects to their hosts. However, due to their ability to transpose into virtually any locus, TEs have the ability to generate deleterious mutations in the host genome. In response, a variety of different mechanisms have evolved to mitigate their activities. A main defense mechanism is RNA silencing, which is a gene silencing mechanism triggered by small RNAs. In this review, we address RNA silencing mechanisms that silence retrotransposons, a subset of TEs, and discuss how germline and somatic cells are equipped with different retrotransposon silencing mechanisms.

本文言語English
ページ(範囲)2473-2478
ページ数6
ジャーナルFEBS Letters
582
17
DOI
出版ステータスPublished - 2008 7 23

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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