@article{10ddc5b727af41c8bcaf08950161b9c4,
title = "How selfish retrotransposons are silenced in Drosophila germline and somatic cells",
abstract = "Transposable elements (TEs) are DNA elements found in the genomes of various organisms. TEs have been highly conserved during evolution, suggesting that they confer advantageous effects to their hosts. However, due to their ability to transpose into virtually any locus, TEs have the ability to generate deleterious mutations in the host genome. In response, a variety of different mechanisms have evolved to mitigate their activities. A main defense mechanism is RNA silencing, which is a gene silencing mechanism triggered by small RNAs. In this review, we address RNA silencing mechanisms that silence retrotransposons, a subset of TEs, and discuss how germline and somatic cells are equipped with different retrotransposon silencing mechanisms.",
keywords = "Argonaute, Drosophila, RNA silencing, Retrotransposon, piRNA, siRNA",
author = "Siomi, {Mikiko C.} and Kuniaki Saito and Haruhiko Siomi",
note = "Funding Information: We are grateful to members of the Siomi laboratory for discussion and comments on the manuscript. This work was supported by Ministry of Education, Culture, Sports, Science and Technology (MEXT) grants to H.S., Japan Society for the Promotion of Science (JSPS) grants to K.S., New Energy and Industrial Technology Development Organization (NEDO) grants to M.C.S. M.C.S. is supported by Core Research for Evolutional Science and Technology (CREST) from Japan Science and Technology Agency (JST). H.S. is a member of the Genome Network Project by MEXT. M.C.S. is Associate Professor of Global Centers of Excellence (GCOE) for Human Metabolomics Systems Biology by MEXT.",
year = "2008",
month = jul,
day = "23",
doi = "10.1016/j.febslet.2008.06.018",
language = "English",
volume = "582",
pages = "2473--2478",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "17",
}