Human blood metabolite timetable indicates internal body time

Takeya Kasukawa, Masahiro Sugimoto, Akiko Hida, Yoichi Minami, Masayo Mori, Sato Honma, Ken Ichi Honma, Kazuo Mishima, Tomoyoshi Soga, Hiroki R. Ueda

研究成果: Article査読

168 被引用数 (Scopus)

抄録

A convenient way to estimate internal body time (BT) is essential for chronotherapy and time-restricted feeding, both of which use body-time information to maximize potency and minimize toxicity during drug administration and feeding, respectively. Previously, we proposed a molecular timetable based on circadian-oscillating substances in multiple mouse organs or blood to estimate internal body time from samples taken at only a few time points. Here we applied this molecular-timetable concept to estimate and evaluate internal body time in humans. We constructed a 1.5-d reference timetable of oscillating metabolites in human blood samples with 2-h sampling frequency while simultaneously controlling for the confounding effects of activity level, light, temperature, sleep, and food intake. By using this metabolite timetable as a reference, we accurately determined internal body time within 3 h from just two anti-phase blood samples. Our minimally invasive, molecular-timetable method with human blood enables highly optimized and personalized medicine.

本文言語English
ページ(範囲)15036-15041
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
109
37
DOI
出版ステータスPublished - 2012 9月 11

ASJC Scopus subject areas

  • 一般

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