Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury

Satoshi Nori, Mohamad Khazaei, Christopher S. Ahuja, Kazuya Yokota, Jan Eric Ahlfors, Yang Liu, Jian Wang, Shinsuke Shibata, Jonathon Chio, Marian H. Hettiaratchi, Tobias Führmann, Molly S. Shoichet, Michael G. Fehlings

研究成果: Article査読

49 被引用数 (Scopus)

抄録

Fehlings and colleagues investigated the use of directly reprogrammed human neural progenitor cells biased toward an oligodendrogenic fate (oNPCs) combined with sustained delivery of chondroitinase ABC to treat chronic spinal cord injury in an immunodeficient rat model. This combinatorial therapy increased long-term survival of oNPCs, facilitated greater oligodendrocyte differentiation, remyelination of the spared axons by engrafted oNPCs, and neurobehavioral recovery.

本文言語English
ページ(範囲)1433-1448
ページ数16
ジャーナルStem cell reports
11
6
DOI
出版ステータスPublished - 2018 12月 11

ASJC Scopus subject areas

  • 生化学
  • 遺伝学
  • 発生生物学
  • 細胞生物学

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