Human-scale liver harvest and decellularization for preclinical research

Kazuki Tajima, Hiroshi Yagi, Yuko Kitagawa

研究成果: Chapter

2 被引用数 (Scopus)

抄録

Decellularized scaffolds are promising for organ regeneration; to facilitate analyses of decellularization and preclinical research, experiments using large animals are indispensable. An efficient protocol using large animals requires the modification of current methods to account for differences in anatomy, size, stiffness, and animal handling. This chapter describes a method for the decellularization of livers from large animals (especially porcine livers), including anesthesia, organ harvest, organ decellularization, and storage, with a summary of potential pitfalls. This methodology can hypothetically be applied to large animals for preclinical studies and subsequent clinical applications.

本文言語English
ホスト出版物のタイトルMethods in Molecular Biology
出版社Humana Press Inc.
ページ327-335
ページ数9
DOI
出版ステータスPublished - 2018

出版物シリーズ

名前Methods in Molecular Biology
1577
ISSN(印刷版)1064-3745

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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