Human-scale liver harvest and decellularization for preclinical research

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Decellularized scaffolds are promising for organ regeneration; to facilitate analyses of decellularization and preclinical research, experiments using large animals are indispensable. An efficient protocol using large animals requires the modification of current methods to account for differences in anatomy, size, stiffness, and animal handling. This chapter describes a method for the decellularization of livers from large animals (especially porcine livers), including anesthesia, organ harvest, organ decellularization, and storage, with a summary of potential pitfalls. This methodology can hypothetically be applied to large animals for preclinical studies and subsequent clinical applications.

元の言語English
ホスト出版物のタイトルMethods in Molecular Biology
出版者Humana Press Inc.
ページ327-335
ページ数9
DOI
出版物ステータスPublished - 2018 1 1

出版物シリーズ

名前Methods in Molecular Biology
1577
ISSN(印刷物)1064-3745

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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    Tajima, K., Yagi, H., & Kitagawa, Y. (2018). Human-scale liver harvest and decellularization for preclinical research. : Methods in Molecular Biology (pp. 327-335). (Methods in Molecular Biology; 巻数 1577). Humana Press Inc.. https://doi.org/10.1007/7651_2018_195