Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging

Eishun Tsuchida, Teruyuki Komatsu, Yasuko Matsukawa, Akito Nakagawa, Hiromi Sakai, Koichi Kobayashi, Makoto Suematsu

研究成果: Article査読

28 被引用数 (Scopus)

抄録

The administration of extracellular, hemoglobin-based oxygen carriers often elicits an acute increase in blood pressure by vasoconstriction. This side effect is now recognized to be due to the depletion of nitric oxide (endothelial-derived relaxing factor) by the extravasuated hemoglobins. We have recently found that the administration of a recombinant human serum albumin (rHSA)-based oxygen carrier involving synthetic tetraphenyporphinatoiron(II) derivative (FeP) (rHSA-FeP) does not induce such hypertensive action, because of its low permeability through the vascular endothelium. The heart rate responses after the rHSA-FeP injection were also negligibly small. Visualization of the intestinal microcirculatory changes clearly revealed the widths of the venule and arteriole to be fairly constant. The entirely synthetic rHSA-FeP becomes a promising material as a new type of red blood cell substitute.

本文言語English
ページ(範囲)257-261
ページ数5
ジャーナルJournal of Biomedical Materials Research - Part A
64
2
DOI
出版ステータスPublished - 2003 2 1

ASJC Scopus subject areas

  • セラミックおよび複合材料
  • 生体材料
  • 生体医工学
  • 金属および合金

フィンガープリント

「Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル