Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset

Michael Heide, Christiane Haffner, Ayako Murayama, Yoko Kurotaki, Haruka Shinohara, Hideyuki Okano, Erika Sasaki, Wieland B. Huttner

研究成果: Article査読

32 被引用数 (Scopus)

抄録

The neocortex has expanded during mammalian evolution. Overexpression studies in developing mouse and ferret neocortex have implicated the human-specific gene ARHGAP11B in neocortical expansion, but the relevance for primate evolution has been unclear. Here, we provide functional evidence that ARHGAP11B causes expansion of the primate neocortex. ARHGAP11B expressed in fetal neocortex of the common marmoset under control of the gene's own (human) promoter increased the numbers of basal radial glia progenitors in the marmoset outer subventricular zone, increased the numbers of upper-layer neurons, enlarged the neocortex, and induced its folding. Thus, the human-specific ARHGAP11B drives changes in development in the nonhuman primate marmoset that reflect the changes in evolution that characterize human neocortical development.

本文言語English
ページ(範囲)546-550
ページ数5
ジャーナルScience
369
6503
DOI
出版ステータスPublished - 2020 7 31

ASJC Scopus subject areas

  • 一般

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