Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain

Masaki Kato, Kazuo Okanoya, Taku Koike, Erika Sasaki, Hideyuki Okano, Shigeru Watanabe, Atsushi Iriki

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Language is a characteristic feature of human communication. Several familial language impairments have been identified, and candidate genes for language impairments already isolated. Studies comparing expression patterns of these genes in human brain are necessary to further understanding of these genes. However, it is difficult to examine gene expression in human brain. In this study, we used a non-human primate (common marmoset; Callithrix jacchus) as a biological model of the human brain to investigate expression patterns of human speech- and reading-related genes. Expression patterns of speech disorder- (FoxP2, FoxP1, CNTNAP2, and CMIP) and dyslexia- (ROBO1, DCDC2, and KIAA0319) related genes were analyzed. We found the genes displayed overlapping expression patterns in the ocular, auditory, and motor systems. Our results enhance understanding of the molecular mechanisms underlying language impairments.

本文言語English
ページ(範囲)26-38
ページ数13
ジャーナルBrain and Language
133
DOI
出版ステータスPublished - 2014 6月

ASJC Scopus subject areas

  • 言語および言語学
  • 実験心理学および認知心理学
  • 言語学および言語
  • 認知神経科学
  • 言語聴覚療法

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