@article{155aa88953c44ccaab357abd693c27cf,
title = "Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain",
abstract = "Language is a characteristic feature of human communication. Several familial language impairments have been identified, and candidate genes for language impairments already isolated. Studies comparing expression patterns of these genes in human brain are necessary to further understanding of these genes. However, it is difficult to examine gene expression in human brain. In this study, we used a non-human primate (common marmoset; Callithrix jacchus) as a biological model of the human brain to investigate expression patterns of human speech- and reading-related genes. Expression patterns of speech disorder- (FoxP2, FoxP1, CNTNAP2, and CMIP) and dyslexia- (ROBO1, DCDC2, and KIAA0319) related genes were analyzed. We found the genes displayed overlapping expression patterns in the ocular, auditory, and motor systems. Our results enhance understanding of the molecular mechanisms underlying language impairments.",
keywords = "Common marmoset, Dyslexia, Gene expression, Language, Specific language impairment, Vocal communication",
author = "Masaki Kato and Kazuo Okanoya and Taku Koike and Erika Sasaki and Hideyuki Okano and Shigeru Watanabe and Atsushi Iriki",
note = "Funding Information: We thank Dr. Toshio Ito (CIEA) for providing adult common marmoset brain samples. We are grateful to the Support Unit for Biomaterial Analysis at the RIKEN BSI Research Resources Center for help with sequence analysis, and to the Support Unit for Animal Resources Development for help with animal care. We also thank Drs. Yumiko Yamazaki and Eiji Matsunaga for helpful discussions. This study was supported by the Japan Society for the Promotion of Science (JSPS) Grant-in-Aids for Young Scientists (B) (21700294 and 23700317; to M.K.); by the Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program) (to A.I. and H.O.); and by the Center for Advanced Research on Logic and Sensibility and the Global COE Program of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan (to S.W.). ",
year = "2014",
month = jun,
doi = "10.1016/j.bandl.2014.03.007",
language = "English",
volume = "133",
pages = "26--38",
journal = "Brain and Language",
issn = "0093-934X",
publisher = "Academic Press Inc.",
}