Human tumor antigens recognized by T-cells

Yutaka Kawakami, Steven A. Rosenberg

研究成果: Review article査読

124 被引用数 (Scopus)

抄録

T-cells play an important role in in vivo tumor rejection in many animal tumor models and in human melanoma. Many human tumor antigens recognized by autologous T-cells have now been identified. These are found to be nonmutated and mutated peptides derived from various self proteins as well as viral proteins. A variety of mechanisms involved in generating these T-cell epitopes on growing cancers have also been identified. However, the role of these identified antigens remains to be evaluated. Passive or active immunotherapies using these identified tumor antigens are being conducted in many institutions. The results obtained from these clinical trials may give us better insight into the role of T-cell responses to each antigen in tumor rejection as well as the development of new antigen-specific immunotherapies for patients with cancer.

本文言語English
ページ(範囲)313-339
ページ数27
ジャーナルImmunologic Research
16
4
DOI
出版ステータスPublished - 1997 1月 1

ASJC Scopus subject areas

  • 免疫学

フィンガープリント

「Human tumor antigens recognized by T-cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル