Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine

Yoshifumi Uwamino; Takashi Yokoyama; Yasunori Sato; Ayako Shibata; Toshinobu Kurafuji; Akiko Tanabe; Masayo Noguchi; Tomoko Arai; Akemi Ohno; Hiromitsu Yokota; Ho Namkoong; Tomoyasu Nishimura; Kenjiro Kosaki; Naoki Hasegawa; Masatoshi Wakui; Mitsuru Murata; Hiromichi Matsushita

doi:10.1016/j.vaccine.2023.01.049

Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine

Yoshifumi Uwamino, Takashi Yokoyama, Yasunori Sato, Ayako Shibata, Toshinobu Kurafuji, Akiko Tanabe, Masayo Noguchi, Tomoko Arai, Akemi Ohno, Hiromitsu Yokota, Ho Namkoong, Tomoyasu Nishimura, Kenjiro Kosaki, Naoki Hasegawa, Masatoshi Wakui, Mitsuru Murata, Hiromichi Matsushita

研究成果: Article › 査読

1 被引用数 (Scopus)

抄録

Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.

本文言語	English
ページ（範囲）	1545-1549
ページ数	5
ジャーナル	Vaccine
巻	41
号	9
DOI	https://doi.org/10.1016/j.vaccine.2023.01.049
出版ステータス	Published - 2023 2月 24

ASJC Scopus subject areas

分子医療
免疫学および微生物学（全般）
獣医学（全般）
公衆衛生学、環境および労働衛生
感染症

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1016/j.vaccine.2023.01.049

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フィンガープリント

「Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Uwamino, Y., Yokoyama, T., Sato, Y., Shibata, A., Kurafuji, T., Tanabe, A., Noguchi, M., Arai, T., Ohno, A., Yokota, H., Namkoong, H., Nishimura, T., Kosaki, K., Hasegawa, N., Wakui, M., Murata, M., & Matsushita, H. (2023). Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine. Vaccine, 41(9), 1545-1549. https://doi.org/10.1016/j.vaccine.2023.01.049

Uwamino, Y, Yokoyama, T, Sato, Y, Shibata, A, Kurafuji, T, Tanabe, A, Noguchi, M, Arai, T, Ohno, A, Yokota, H, Namkoong, H, Nishimura, T , Kosaki, K , Hasegawa, N , Wakui, M, Murata, M & Matsushita, H 2023, 'Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine', Vaccine, vol. 41, no. 9, pp. 1545-1549. https://doi.org/10.1016/j.vaccine.2023.01.049

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abstract = "Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.",

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AU - Shibata, Ayako

AU - Kurafuji, Toshinobu

AU - Tanabe, Akiko

AU - Noguchi, Masayo

AU - Arai, Tomoko

AU - Ohno, Akemi

AU - Yokota, Hiromitsu

AU - Namkoong, Ho

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AU - Wakui, Masatoshi

AU - Murata, Mitsuru

AU - Matsushita, Hiromichi

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