Hydroxylation of benzene by horseradish peroxidase and immobilized horseradish peroxidase in an organic solvent

Reiko Akasaka, Tadahiko Mashino, Masaaki Hirobe

研究成果: Article

13 被引用数 (Scopus)

抄録

Horseradish peroxidase (HRP) catalyzed hydroxylation of benzene with an oxidant when benzene was used as the reaction solvent. HRP immobilized on poly(γ-methyl-L-glutamate) also catalyzed the reaction with higher activity than that of free HRP. The results of the reaction using [18O]hydrogen peroxide show that free and immobilized HRP incorporated the oxygen atom of the reactive species into the product, indicating that both forms of HRP can catalyze hydroxylation of benzene in an analogous manner to that of cytochrome P450.

本文言語English
ページ(範囲)1861-1864
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
5
16
DOI
出版ステータスPublished - 1995 8 17
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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