Hypercapnic acidosis minimizes endotoxin-induced gut mucosal injury in rabbits

Hiroshi Morisaki, Satoshi Yajima, Yoko Watanabe, Takeshi Suzuki, Michiko Yamamoto, Nobuyuki Katori, Saori Hashiguchi, Junzo Takeda

研究成果: Article

8 引用 (Scopus)

抄録

Recent evidence demonstrated that hypercapnic acidosis due to lung protective strategy was not only permissive but also even therapeutic for injured lung. Since the effects of hypercapnic acidosis on extra-pulmonary organs remain to be clarified, we tested the hypothesis that hypercapnic acidosis protects gut mucosal barrier function by modulating inflammation in a rabbit model of endotoxemia. Prospective randomized animal study. University research laboratory. Male New Zealand white rabbits. Thirty-two animals were randomly allocated into two groups: normocapnia (n = 17) and hypercapnia (n = 15). The latter group received FICO2 5% under mechanical ventilation to achieve hypercapnia throughout the study periods, whereas the former with FICO2 0%. Arterial blood gas, intramucosal pH (pHi) and portal blood flow were assessed at baseline, 2-h and 4-h infusion of lipopolysaccharide. At 4 h, ileal myeloperoxidase (MPO) activity and intestinal permeability were measured. The animals in the hypercapnia group showed apparent hypercapnic acidosis and progressive intramucosal acidosis at 4 h, accompanied by significantly lower intestinal permeability versus normocapnia group. Ileal MPO activity was comparable between the study groups. Hypercapnic acidosis attenuates endotoxin-induced gut barrier dysfunction possibly through neutrophil-independent mechanisms.

元の言語English
ページ(範囲)129-135
ページ数7
ジャーナルIntensive Care Medicine
35
発行部数1
DOI
出版物ステータスPublished - 2009 1

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Acidosis
Endotoxins
Rabbits
Hypercapnia
Wounds and Injuries
Lung
Peroxidase
Permeability
Endotoxemia
Artificial Respiration
Lipopolysaccharides
Neutrophils
Gases
Inflammation
Research

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

これを引用

Morisaki, H., Yajima, S., Watanabe, Y., Suzuki, T., Yamamoto, M., Katori, N., ... Takeda, J. (2009). Hypercapnic acidosis minimizes endotoxin-induced gut mucosal injury in rabbits. Intensive Care Medicine, 35(1), 129-135. https://doi.org/10.1007/s00134-008-1212-7

Hypercapnic acidosis minimizes endotoxin-induced gut mucosal injury in rabbits. / Morisaki, Hiroshi; Yajima, Satoshi; Watanabe, Yoko; Suzuki, Takeshi; Yamamoto, Michiko; Katori, Nobuyuki; Hashiguchi, Saori; Takeda, Junzo.

:: Intensive Care Medicine, 巻 35, 番号 1, 01.2009, p. 129-135.

研究成果: Article

Morisaki, H, Yajima, S, Watanabe, Y, Suzuki, T, Yamamoto, M, Katori, N, Hashiguchi, S & Takeda, J 2009, 'Hypercapnic acidosis minimizes endotoxin-induced gut mucosal injury in rabbits', Intensive Care Medicine, 巻. 35, 番号 1, pp. 129-135. https://doi.org/10.1007/s00134-008-1212-7
Morisaki, Hiroshi ; Yajima, Satoshi ; Watanabe, Yoko ; Suzuki, Takeshi ; Yamamoto, Michiko ; Katori, Nobuyuki ; Hashiguchi, Saori ; Takeda, Junzo. / Hypercapnic acidosis minimizes endotoxin-induced gut mucosal injury in rabbits. :: Intensive Care Medicine. 2009 ; 巻 35, 番号 1. pp. 129-135.
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