Hypermethylation in the p16 promoter region in the carcinogenesis of endometrial cancer in Japanese patients

Megumi Yanokura, Kouji Banno, Nobuyuki Susumu, Makiko Kawaguchi, Yoshiko Kuwabara, Kastumi Tsukazaki, Daisuke Aoki

研究成果: Article

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Background: p16 has been reported to disappear by hypermethylation in various cancers. However, the relationship between the frequency of hypermethylation of p16 and the mechanism of its inactivation has not been completely elucidated in endometrial cancer. Materials and Methods: Hypermethylation in the promoter region of the p16 gene and the expression of the p16 protein in 51 specimens, including 8 endometrial cancer cell lines, 7 normal endometrial tissues, 12 atypical endometrial hyperplasia tissues and 32 endometrial cancer tissues were analyzed. Results: Five out of 8 endometrial cancer cell lines showed hypermethylation with high frequency, although only 1 showed loss of gene expression. However, no endometrial cancer tissue of the 32 specimens showed hypermethylation. Furthermore, loss of expression was immunohistochemically observed in 3 out of the 20 specimens. Conclusion: These results suggest that hypermethylation of p16 rarely occurs and, thus, has no significant effect on the carcinogenesis of endometrial cancer in Japanese patients.

元の言語English
ページ(範囲)851-856
ページ数6
ジャーナルAnticancer research
26
発行部数2 A
出版物ステータスPublished - 2006 3 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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