[Hypertension and arteriosclerosis].

Hiroyuki Sasamura, Hiroshi Itoh

研究成果: Review article

1 引用 (Scopus)

抄録

Hypertension is a known risk factor for arteriosclerosis, and causes both atherosclero= sis of medium-large arteries and arteriolosclerosis of the arterioles. Elevated blood pressure causes damage to the endothelium and vascular wall through both mechanical and humoral factors. We and others have shown that inhibition of the renin-angiotensin system at a 'critical period' during the development of hypertension results in a permanent suppression of hypertension in animal models. We have also reported that high-dose renin-angiotensin inhibition results in regression of hypertension, possibly by regression of renal arteriolar hypertrophy. These results suggest that understanding the process of arterial remodeling may play a key role in the development of new strategies for prevention and regression of hypertension and arteriosclerosis.

元の言語English
ページ(範囲)125-130
ページ数6
ジャーナルNippon rinsho. Japanese journal of clinical medicine
69
発行部数1
出版物ステータスPublished - 2011 1
外部発表Yes

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Arteriosclerosis
Hypertension
Arteriolosclerosis
Vascular Endothelium
Angiotensins
Arterioles
Renin-Angiotensin System
Renin
Hypertrophy
Animal Models
Arteries
Blood Pressure
Kidney

ASJC Scopus subject areas

  • Medicine(all)

これを引用

[Hypertension and arteriosclerosis]. / Sasamura, Hiroyuki; Itoh, Hiroshi.

:: Nippon rinsho. Japanese journal of clinical medicine, 巻 69, 番号 1, 01.2011, p. 125-130.

研究成果: Review article

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