Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.
|ジャーナル||Journal of the American Chemical Society|
|出版ステータス||Published - 2010 11月 17|
ASJC Scopus subject areas
- 化学 (全般)