TY - JOUR
T1 - Hysteroscopic treatment assisted by photodynamic diagnosis for atypical polypoid adenomyoma
T2 - A report of two cases
AU - Matoba, Yusuke
AU - Banno, Kouji
AU - Kobayashi, Yusuke
AU - Yamagami, Wataru
AU - Nakamura, Masaru
AU - Kisu, Iori
AU - Aoki, Daisuke
N1 - Funding Information:
We thank SBI Pharmaceuticals (Minato-Ku, Tokyo, Japan) for providing 5-aminolevulinic acid hydrochloride and MC Medical, Inc. (Minato-Ku, Tokyo, Japan) for allowing free use of an endoscopic device with a D-Light System. This study was supported by a JFE (Japanese Foundation for Research and Promotion of Endoscopy) Grant 2018.
Funding Information:
We thank SBI Pharmaceuticals (Minato-Ku, Tokyo, Japan) for providing 5-aminolevulinic acid hydrochloride and MC Medical, Inc. (Minato-Ku, Tokyo, Japan) for allowing free use of an endoscopic device with a d -Light System. This study was supported by a JFE (Japanese Foundation for Research and Promotion of Endoscopy) Grant 2018.
Publisher Copyright:
© 2021 The Author(s)
PY - 2021/12
Y1 - 2021/12
N2 - Atypical polypoid adenomyoma (APA) is an intrauterine tumor for which hysteroscopic tumor resection allows for fertility preservation. Complete resection is important because of the high recurrence rate of APA, but is difficult due to the lack of characteristic hysteroscopic findings. We previously reported a case in which photodynamic diagnosis (PDD) was useful for detection of APA. Here, we report two additional cases of APA treated by hysteroscopic resection with PDD. The procedure was approved by the ethical committee. Case 1: A 35-year-old female who underwent hysteroscopic surgery for a submucosal tumor suspected to be APA with hypermenorrhea. Case 2: A 37-year-old female in whom hysteroscopic surgery was performed for a residual APA lesion after hormone therapy. In Case 1, PDD identified the tumor borders and this enabled as complete resection as possible. In Case 2, lesions could not be identified clearly under white light, but some areas were PDD-positive and were excised. Among 19 specimens from these two cases and the previously reported case, all PDD-positive specimens were pathologically diagnosed as APA. The sensitivity and specificity of PDD for APA were 76.9% and 100%, respectively. These results suggest that PDD can contribute to identification of APA.
AB - Atypical polypoid adenomyoma (APA) is an intrauterine tumor for which hysteroscopic tumor resection allows for fertility preservation. Complete resection is important because of the high recurrence rate of APA, but is difficult due to the lack of characteristic hysteroscopic findings. We previously reported a case in which photodynamic diagnosis (PDD) was useful for detection of APA. Here, we report two additional cases of APA treated by hysteroscopic resection with PDD. The procedure was approved by the ethical committee. Case 1: A 35-year-old female who underwent hysteroscopic surgery for a submucosal tumor suspected to be APA with hypermenorrhea. Case 2: A 37-year-old female in whom hysteroscopic surgery was performed for a residual APA lesion after hormone therapy. In Case 1, PDD identified the tumor borders and this enabled as complete resection as possible. In Case 2, lesions could not be identified clearly under white light, but some areas were PDD-positive and were excised. Among 19 specimens from these two cases and the previously reported case, all PDD-positive specimens were pathologically diagnosed as APA. The sensitivity and specificity of PDD for APA were 76.9% and 100%, respectively. These results suggest that PDD can contribute to identification of APA.
KW - 5-aminolevulinic acid
KW - Atypical polypoid adenomyoma
KW - Hysteroscopy
KW - Photodynamic diagnosis
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U2 - 10.1016/j.pdpdt.2021.102583
DO - 10.1016/j.pdpdt.2021.102583
M3 - Article
C2 - 34673272
AN - SCOPUS:85118328542
VL - 36
JO - Photodiagnosis and Photodynamic Therapy
JF - Photodiagnosis and Photodynamic Therapy
SN - 1572-1000
M1 - 102583
ER -